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    Association details:
    Biomarker:SSTR2 expression
    Cancer:Non Small Cell Lung Cancer
    Drug:paclitaxel (Bcl2 inhibitor, Tubulin polymerization promoter) +
    Mycapssa (octreotide) (SSTR agonist)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Thorac Cancer
    Title:

    Targeted paclitaxel-octreotide conjugates inhibited the growth of paclitaxel-resistant human non-small cell lung cancer A549 cells in vitro

    Published date:
    10/06/2021
    Excerpt:
    PTX-OCT and 2PTX-OCT significantly inhibited the growth and induced apoptosis of SSTR2- and SSTR5-positive A549 cells, compared with the control (p < 0.01), and had less inhibitory effect on SSTR2- and SSTR5-negative H157 cells than paclitaxel (p < 0.01).
    DOI:
    10.1111/1759-7714.14182