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Association details:
| Biomarker: | SPARC overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | docetaxel (Tubulin polymerization promoter, Microtubule stabilizer) + doxorubicin hydrochloride (Topoisomerase II inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer
Excerpt:
100 female patients with newly diagnosed locally advanced or metastatic breast cancer were recruited into a prospective phase II study and randomized to one of two alternating sequences of doxorubicin 75 mg/m2 (A) and docetaxel 75 mg/m2 (T)...Increased expression of THBS1 and TNC...High baseline THBS1 and SPARC were significantly associated with poorer OS (Figure 2A–2B), and high baseline SPARC was an independent prognostic marker in multivariate analysis (HR adjusted 3.78, 95% CI 1.03–13.92, p = 0.045)…
DOI:
10.18632/oncotarget.10894
