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Association details:
| Biomarker: | SP140 overexpression |
|---|---|
| Cancer: | Melanoma |
| Drug Class: | PD1 inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response
Published date:
12/13/2022
Excerpt:
Examining the dataset of metastatic melanoma patients who underwent CTLA-4 blockade immunotherapy, we found significantly more favorable survival in patients who had high SP140 levels (n=12) than in patients with low levels of SP140 (n=28) (log-rank test, p=4.98E-3)....Similar results were found in metastatic melanomas which were treated with anti-PD-1 immune blockade.
DOI:
10.1136/jitc-2022-005088
