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Association details:
| Biomarker: | SOX9 overexpression |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug: | tamoxifen (Estrogen receptor antagonist) |
| Direction: | Resistant |
Evidence:
Source:
Title:
RUNX3/SOX9 Expression in Relapsed ER+ Breast Cancer
Published date:
02/22/2021
Excerpt:
20 pairs of primary/relapsed formalin fixed paraffin embedded (FFPE) tissues of hormone receptor-positive breast cancer patients treated with tamoxifen from 2008....The expression of RUNX3 in relapsed specimen was significantly lower than that of the paired primary specimen (P = 0.0410), and the expression of SOX9 in the relapsed specimen was significantly higher than that of the corresponding primary specimen (P = 0.0496) (Figure 1).
