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Association details:
| Biomarker: | SOX10 underexpression |
|---|---|
| Cancer: | Melanoma |
| Drug Class: | BRAF inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
40 - Targeting SOX10-deficient cells to reduce resistance to targeted therapy in melanoma
Published date:
03/10/2021
Excerpt:
...melanoma models...cell lines generated from xenograft tumors that have acquired resistance to either vemurafenib, paradox-breaking BRAFi or the combination of BRAFi + MEKi showed dramatically reduced SOX10 expression compared to their parental counterparts.
