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    Association details:
    Biomarker:SMTN P641A
    Cancer:Non Small Cell Lung Cancer
    Drug:Erivedge (vismodegib) (Hedgehog cell-signalling pathway inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    New
    Source:
    J Clin Oncol
    Title:

    Germline and Somatic Smoothened Mutations in Non–Small-Cell Lung Cancer Are Potentially Responsive to Hedgehog Inhibitor Vismodegib

    Excerpt:
    In this case report, we identified a novel germline SMO P641A mutation in a nonsmoking patient with lung SCC who achieved a durable antitumor response with vismodegib.
    DOI:
    10.1200/PO.17.00149