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Association details:
| Biomarker: | SMARCA4 mutation |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
SMARCA4 Depletion Induces Cisplatin Resistance by Activating YAP1-Mediated Epithelial-to-Mesenchymal Transition in Triple-Negative Breast Cancer
Published date:
10/30/2021
Excerpt:
We investigated the clinical implication and downstream regulation induced by SMARCA4 inactivation using large-scale genome and transcriptome profiles....First, we observed an increase in SMARCA4 mutations in cisplatin resistance and metastasis in TNBC patients.
DOI:
10.3390/cancers13215474
