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Association details:
| Biomarker: | SMAD4 mutation |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | oxaliplatin (DNA synthesis inhibitor, DNA cross linking agent) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
34P - Molecular markers of response to different chemotherapeutic agents in RAS / BRAF mutated colon cancer cell lines
Published date:
09/14/2020
Excerpt:
The following colon cancer cell lines were used: HCT15, T84, HT29 and SW480 (molecular characteristics are summarized in the table). These cell lines were assigned to 5-fluorouracil, oxaliplatin, irinotecan, gemcitabine, pemetrexed, trabectidine and eribulin at different doses...The results of IC50 (μM) obtained in the colon cancer cell lines for the different drugs are summarized in the table. In the case of ERIB, the most resistant line is the one that expresses P-glycoprotein.
