All patients received adjuvant gemcitabine….Ten (8%) patients had intact SMAD4 expression….On univariate analysis, SMAD4 expression was associated with increased locoregional recurrence (hazard ratio 7.0, P<0.01, 95% confidence interval: 2.8–18.0) but not distant recurrence (P=0.06) or overall survival (P=0.73)....On multivariable analysis, intact SMAD4 expression was associated with a higher rate of LRR (HR 9.6, P≤0.01, 95% CI: 3.7–24.8)...in a cohort of patients with resected pancreas cancer, intact SMAD4 expression was associated with a locally aggressive phenotype with a markedly increased risk of LRR.