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Association details:
| Biomarker: | SLITRK6 expression |
|---|---|
| Cancer: | Lung Cancer |
| Drug: | sirtratumab vedotin (ASG-15ME) (Microtubule inhibitor, SLITRK6-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Development of ASG-15ME, a Novel Antibody–Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker
Excerpt:
Because SLITRK6 is also expressed in a subset of lung cancer specimens, studies were carried out in the lung cancer xenograft model, NCI-H322M. In this study, ASG-15ME was significantly better than ASG-15MF at inhibiting tumor growth (P < 0.0001) and was able to cause 99% tumor growth inhibition.
DOI:
https://doi.org/10.1158/1535-7163.MCT-15-0570
