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Association details:
| Biomarker: | SLIT2 expression |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | pemetrexed (Thymidylate synthase inhibitor, THF dehydrogenase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
EP16.03-029 - SLIT2 Expression in NSCLC With Long-Term Response to Pemetrexed
Published date:
07/12/2022
Excerpt:
In GeneSpring analysis, 12 genes which were 5 fold higher in sensitive cell lines than in resistant cell lines were chosen. Among them, tumor-related genes were SLIT2 and synovial sarcoma X (SSX) 3. SLIT2 is one of tumor suppression genes, which was expressed with IHC in 3 NSCLCs with the response to pemetrexed over 12 months....It was suggested that SLIT2 would predict the long-term response to pemetrexed.