^
Association details:
Biomarker:SLC3A2 expression
Cancer:Prostate Cancer
Drug:erastin (Ferroptosis inducer)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer

Published date:
01/22/2021
Excerpt:
In this study, we demonstrate that mediators of ferroptosis SLC7A11, SLC3A2 and GPX4 are expressed in treatment-resistant prostate cancer. We further demonstrate that treatment-resistant prostate cancer cells are sensitive to two ferroptosis inducers, erastin and RSL3.
DOI:
10.1158/0008-5472.CAN-20-3477