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Association details:
| Biomarker: | SLC39A6 expression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | ladiratuzumab vedotin (SGN-LIV1A) (Microtubule inhibitor, LIV-1-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
SGN–LIV1A: A Novel Antibody–Drug Conjugate Targeting LIV-1 for the Treatment of Metastatic Breast Cancer
Excerpt:
SGN–LIV1A displays specific in vitro cytotoxic activity against LIV-1–expressing cancer cells. In vitro results are recapitulated in vivo where antitumor activity is demonstrated in tumor models of breast...These results support the clinical evaluation of SGN–LIV1A as a novel therapeutic agent for patients with LIV-1–expressing cancer.
DOI:
10.1158/1535-7163.MCT-13-0896
