^
    Back
    Association details:
    Biomarker:SH3BGRL overexpression
    Cancer:Breast Cancer
    Drug:doxorubicin hydrochloride (Topoisomerase II inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    Autophagy
    Title:

    Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers

    Published date:
    12/06/2021
    Excerpt:
    Here, we demonstrate that a small adaptor protein, SH3BGRL, is not only elevated in the majority of breast cancer patients but also has relevance with the relapse and poor prognosis of breast cancer patients. Functionally, SH3BGRL upregulation enhances the chemoresistance of breast cancer cells to the first-line doxorubicin treatment through macroautophagic/autophagic protection.
    DOI:
    10.1080/15548627.2021.2002108