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Association details:
| Biomarker: | SF3B1 K700E |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug: | spliceostatin A (SSA) (SF3B1 inhibitor, RNA splicing modulator) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
SF3B1 mutations constitute a novel therapeutic target in breast cancer
Excerpt:
Additional profiling of hotspot mutations in a panel of special histological subtypes of breast cancer showed that 16% and 6% of papillary and mucinous carcinomas of the breast harboured the SF3B1 K700E mutation….SF3B1 mutant cell lines were found to be sensitive to the SF3b complex inhibitor spliceostatin A and treatment resulted in perturbation of the splicing signature.
DOI:
10.1002/path.4483
