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    Association details:
    Biomarker:SEZ6 expression
    Cancer:Small Cell Lung Cancer
    Drug:ABBV-011 (DNA minor groove binder, SEZ6-targeted antibody-drug conjugate)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Mol Cancer Ther
    Title:

    ABBV-011, A Novel, Calicheamicin-Based Antibody–Drug Conjugate, Targets SEZ6 to Eradicate Small Cell Lung Cancer Tumors

    Published date:
    06/01/2022
    Excerpt:
    We next tested the antitumor activity of ABBV-011 using PDX models of SCLC...A single dose of ABBV-011 resulted in significant, and dose-dependent tumor regression in LU64, a SEZ6-positive PDX line…
    DOI:
    https://doi.org/10.1158/1535-7163.MCT-21-0851