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Association details:
| Biomarker: | SAMHD1 expression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | capecitabine (Thymidylate synthase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Prognostic and predictive value of SAMHD1 espression in solid tumors
Published date:
05/28/2021
Excerpt:
...explored the potential rol of SAMHD1 expression in advanced non-small cell lung (NSCLC), ovarian (OC) and breast cancer (BC) patients (p)...included 46 BC p treated with capecitabine...SAMHD1 positivity was associated with shorter disease free survival interval (DFS) in OC, NSCLC, and BC p (χ²test; p=.010, p.003, p=.005, respectively)....SAMHD1 positivity was associated with shorter OS and OSDC for BC p (p=.05 and p=.001, respectively), in special in luminal B subgroup.
