^
Association details:
| Biomarker: | RRM1 underexpression |
|---|---|
| Cancer: | Adrenal Cortex Carcinoma |
| Drug: | Lysodren (mitotane) (Steroid receptor inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Ribonucleotide reductase large subunit (RRM1) gene expression may predict efficacy of adjuvant mitotane in adrenocortical cancer
Excerpt:
...high RRM1 gene expression was associated to shorter disease-free survival (DFS) and overall survival at both univariate and multivariate analysis. In patients with low RRM1 gene expression, adjuvant mitotane was associated with improved DFS, whereas this effect was lost in cases with high RMM1 expression...
DOI:
10.1158/1078-0432.CCR-11-2692
