We enrolled 24 IIB-IIIC NSCLC patients who did not harbore any EGFR, ALK and ROS-1 driver mutations were treated with Tislelizumab plus chemotherapy...After surgery, pathological response were evaluated and MPR was 37.5%, pCR was 29.2%....Tislelizumab plus chemotherapy were effective in early or locally advanced NSCLC patients as neoadjuvant treatment.