TQ-B3139 was administered orally from 50mg~100mg qd and 200, 300, 400, 500, 600 and 800mg bid, using a PK-guided modified...totally 63 patients (59 ALK+, 4 ROS1+) were enrolled….Overall ORR was 73.0% (2 CR, 44 PR); DCR was 85.7% (8 SD)….Objective response was observed from dose level 200mg bid cohort, ORR and DCR at ≥200mg bid was 78.0% and 89.8%....TQ-B3139 was well tolerated in Chinese NSCLC patients with high antitumor activity.