We assayed three DNA-damaging agents (cisplatin, dacarbazine, and lomustine), a topoisomerase inhibitor (camptothecin), and a microtubule inhibitor (paclitaxel). Following treatment with each of these drugs, both A375 and UACC903 cells overexpressing ROR2 presented reduced cell death...These results indicate that ROR2 promotes chemoresistance of melanoma cells to cytotoxic compounds with different mechanisms of action by inhibiting apoptosis.