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Association details:
| Biomarker: | ROR1 underexpression |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | STRO-003 (Topoisomerase I inhibitor, ROR1-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
STRO-003 is a novel ROR1-targeted ADC for breast and lung cancer
Published date:
11/08/2022
Excerpt:
STRO-003 has exhibited potent and specific activity in xenograft models for TNBC and lung cancer, and importantly, elicited significant anti-tumor suppression in a panel of NSCLC PDx models, including those with low ROR1 expression...Our data suggests that STRO-003 is a promising clinical candidate for solid tumor indications and we have initiated IND-enabling studies.
DOI:
10.1136/jitc-2022-SITC2022.1191
Source:
Title:
STRO-003 is a novel ROR1-targeted ADC for breast and lung cancer
Excerpt:
STRO-003 has exhibited potent and specific activity in xenograft models for TNBC and lung cancer, and importantly, elicited significant anti-tumor suppression in a panel of NSCLC PDx models, including those with low ROR1 expression…Our data suggests that STRO-003 is a promising clinical candidate for solid tumor indications and we have initiated IND-enabling studies.
DOI:
10.1136/jitc-2022-SITC2022.1191
