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Association details:
| Biomarker: | ROR1 positive |
|---|---|
| Cancer: | Leukemia |
| Drug: | NBE-002 (DNA replication inhibitor, ROR1-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia
Published date:
08/24/2021
Excerpt:
We found that huXBR1-402-G5-PNU is cytotoxic to proliferating ROR1+ malignant cells in vitro and suppressed leukemia proliferation and extended survival in multiple models of mice engrafted with human ROR1+ leukemia…Together, our data present compelling preclinical evidence for the efficacy of huXBR1-402-G5-PNU in treating ROR1+ hematologic malignancies.
DOI:
10.1182/bloodadvances.2020003276
