^
Association details:
| Biomarker: | ROR1 positive |
|---|---|
| Cancer: | Chronic Lymphocytic Leukemia |
| Drug: | zilovertamab vedotin (MK-2140) (Microtubule inhibitor, ROR1-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ROR1 targeting with the antibody drug-conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models
Published date:
01/14/2021
Excerpt:
Treatment options for RS are limited and the disease is often fatal. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is expressed on CLL cells...In systemic ROR1+ RS-PDXs, VLS-101 dramatically decreased tumor burden in all RS-colonized tissues and significantly prolonged survival.
DOI:
10.1182/blood.2020008404
