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Association details:
| Biomarker: | ROR1 expression |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | zilovertamab (UC-961) (ROR1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
PD07-04 PRE-CLINICAL STUDIES FOR ADVANCING CIRMTUZUMAB-BASED ANTI-ROR1 THERAPIES IN METASTATIC PROSTATE CANCER
Published date:
04/09/2022
Excerpt:
Westerns showed increased expression of ROR1 in the neuroendocrine prostate cancer cell lines, PC3 and DU145, and a patient derived xenograft (PDX) model of small cell bone metastatic prostate cancer, PCSD13….Intravenous infusion of anti-ROR1 CAR-T cells into mice bearing subcutaneous, ROR1-expressing, PC3 xenografts, showed marked reduction in tumor growth. ROR1 Knock out using CRISPR-Cas9 in PC3 and DU145 cells showed specificity of Cirmtuzumab-based immunotherapies.
DOI:
https://doi.org/10.1097/JU.0000000000002526.04
