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Association details:
| Biomarker: | ROR1 expression |
|---|---|
| Cancer: | Mantle Cell Lymphoma |
| Drug: | zilovertamab vedotin (MK-2140) (Microtubule inhibitor, ROR1-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting ROR1 Using the Antibody Drug Conjugate Vls-101 in Aggressive Mantle Cell Lymphoma
Published date:
11/04/2020
Excerpt:
All 5 cell lines and all 9 PDX models of MCL tested showed high ROR1 mRNA and protein expression levels...VLS-101 treatment of ibrutinib-venetoclax dual-resistant ROR1+ PDX model resulted in significant regressions of the tumor bearing spleens and livers.
