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Association details:
| Biomarker: | ROR1 expression |
|---|---|
| Cancer: | Acute Lymphocytic Leukemia |
| Drug: | zilovertamab vedotin (MK-2140) (Microtubule inhibitor, ROR1-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
3038 - Evaluation of ROR1-targeted antibody-drug conjugates against ROR1-expressing pediatric preclinical models - a report from the pediatric preclinical testing consortium (PPTC)
Published date:
03/10/2021
Excerpt:
ALL models with elevated ROR1 expression...At the highest doses of each ADC studied, 2 of 6 (VLS-101) and 3 of 6 (VLS-211) ROR1-expressing models showed objective responses.
