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    Association details:
    Biomarker:RNF43 659
    Cancer:Colorectal Cancer
    Drug Class:PI3K inhibitor
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Nat Commun
    Title:

    RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition

    Published date:
    06/08/2022
    Excerpt:
    PI3K/mTOR inhibitors yield promising antitumor activity in RNF43659mut isogenic cell lines and xenograft models, as well as in patient-derived organoids harboring RNF43_p.G659fs mutations.
    DOI:
    10.1038/s41467-022-30794-7