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Association details:
| Biomarker: | RNF43 659 |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug Class: | mTOR inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition
Published date:
06/08/2022
Excerpt:
PI3K/mTOR inhibitors yield promising antitumor activity in RNF43659mut isogenic cell lines and xenograft models, as well as in patient-derived organoids harboring RNF43_p.G659fs mutations.
DOI:
10.1038/s41467-022-30794-7
