^
Association details:
| Biomarker: | RIT1 overexpression |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug: | sorafenib (Multi-tyrosine kinase inhibitor, pan-RAF inhibitor) |
| Drug Class: | AKT inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Elevated expression of RIT1 hyperactivates RAS/MAPK signal and sensitizes hepatocellular carcinoma to combined treatment with sorafenib and AKT inhibitor
Excerpt:
...we treated RIT1-overexpressing HCC with combined regimen sorafenib plus AKT inhibitor, and achieved enhanced antitumor effects in vivo.
DOI:
10.1038/s41388-021-02130-8