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Association details:
| Biomarker: | RICTOR amplification |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | dactolisib (RTB101) (mTOR inhibitor, PI3K inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Rapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated mTORC1/2 inhibition
Excerpt:
MTT proliferation assays showed increased sensitivity to the dual mTORC1/2 inhibitor AZD2014 and the dual PI3K/mTOR compound BEZ235 (Figure 2B)...among the various inhibitors tested, AZD2014 showed the most potent inhibitory effect onRICTOR-amplified GC PDCs.
DOI:
10.1093/annonc/mdw669
