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    Association details:
    Biomarker:RET-PTC1 rearrangement
    Cancer:Thyroid Gland Papillary Carcinoma
    Drug:CI-1040 (MEK inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Head Neck
    Title:

    Src Inhibitors Suppress the Growth of Papillary Thyroid Carcinoma

    Excerpt:
    In TPC-1 cells after 4 days of treatment, the cell growth was repressed for 36.2 or 71.4% (p < 0.001) by 0.1 or 1 μM PP2, 29.9 or 61.4% (p < 0.001) by 0.1 or 1 μM SU6656, or 36.7 or 69.2% (p < 0.001) by 0.01 or 0.1 μM dasatinib, respectively, when compared to untreated cells...
    DOI:
    10.1002/hed.23316
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Endocrine Society
    Title:

    Inhibitory Effects of the Mitogen-Activated Protein Kinase Kinase Inhibitor CI-1040 on the Proliferation and Tumor Growth of Thyroid Cancer Cells with BRAF or RAS Mutations

    Excerpt:
    Genotypes of various thyroid cancer cell lines and their sensitivity to inhibition by CI-1040.
    DOI:
    https://doi.org/10.1210/jc.2007-0097