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Association details:
Biomarker:RET M918T
Cancer:Thyroid Gland Carcinoma
Drug:HG-6-63-01 (RET inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Title:

Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase

Excerpt:
At a concentration of 10 nM, ALW-II-41-27, XMD15-44 and HG-6-63-01 inhibited RET kinase and signaling in human thyroid cancer cell lines carrying oncogenic RET alleles; they also inhibited proliferation of cancer....Inhibition of RET/C634R and RET/M918T phosphorylation and downstream signaling by ALW-II-41-27, XMD15-44 and HG-6-63-01.
DOI:
10.1371/journal.pone.0128364