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    Association details:
    Biomarker:RET C634W
    Cancer:Thyroid Gland Papillary Carcinoma
    Drug:AZD1480 (JAK2 inhibitor, JAK1 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    PLoS One
    Title:

    AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines

    Excerpt:
    Thyroid cancer cell lines harboring RET/PTC1 (TPC-1), RET M918T (MZ-CRC1) and RET C634W (TT) alterations....AZD1480 effectively blocks proliferation and tumor growth of activated RET- thyroid cancer cell lines…
    DOI:
    10.1371/journal.pone.0046869