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Association details:
| Biomarker: | RET C634R |
|---|---|
| Cancer: | Thyroid Gland Carcinoma |
| Drug: | ALW-II-41-27 (EphA2 receptor antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase
Excerpt:
At a concentration of 10 nM, ALW-II-41-27, XMD15-44 and HG-6-63-01 inhibited RET kinase and signaling in human thyroid cancer cell lines carrying oncogenic RET alleles; they also inhibited proliferation of cancer....Inhibition of RET/C634R and RET/M918T phosphorylation and downstream signaling by ALW-II-41-27, XMD15-44 and HG-6-63-01.
DOI:
10.1371/journal.pone.0128364
