^
Association details:
| Biomarker: | REST signature |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | linsitinib (ASP7487) (IGF-1R inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
An expression based REST signature predicts patient survival and therapeutic response for glioblastoma multiforme
Excerpt:
...we developed an expression based REST signature and assessed its association with transcriptomics, genomics, drug sensitivity and clinical outcome for GBM in this article....Linsitinib, an IGF1R inhibitor...emerged as the top hit associated with enhanced activity in REST-high cell lines (Fig. 4A).
DOI:
10.1038/srep34556
