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Association details:
| Biomarker: | RECQL5 mutation + TMB-H |
|---|---|
| Cancer: | Melanoma |
| Drug Class: | Immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
RECQL5 mutations as a potential efficacious predictor of immunotherapy in melanoma patients
Published date:
05/19/2021
Excerpt:
In the three melanoma cohorts (Van Allen, Synder, Miao) with OS data available, the OS of the RECQL5-mutated patients was 2 to 3 times longer than that of the RECQL5-wt patients….RECQL5 mutations can serve as a potential predictor for a durable response to ICIs in melanoma. Moreover, the occurrence of RECQL5 mutations was correlated with higher TMB level...
DOI:
10.1200/JCO.2021.39.15_suppl.e21547
