^
Association details:
| Biomarker: | RB1 overexpression |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | Ibrance (palbociclib) (CDK4 inhibitor, CDK6 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS
Excerpt:
Biochemically, PD0332991-sensitive cell lines (OVCA420, OVCA433, HEY, DOV13) had low expression of cyclin E1 RNA and protein with concomitant high expression of RB protein (Supplementary Fig. 1a).
DOI:
10.18632/oncotarget.2673
