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Association details:
| Biomarker: | RASGRP1 overexpression |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | mirdametinib (PD-0325901) (MEK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Response and Resistance to MEK Inhibition in Leukaemias Initiated by Hyperactive Ras
Excerpt:
To further assess the functional importance of Rasgrp1 over-expression in resistant AML #6554, we infected the sensitive and resistant leukaemias with a lentiviral vector encoding both a short hairpin RNA that efficiently reduces RasGRP1 protein...A provocative implication of our studies of AML #6554 showing that Rasgrp1 over-expression modulates the response to MEK inhibitors.
DOI:
10.1038/nature08279
