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Association details:
| Biomarker: | RANBP2-ALK + TMEM217-ALK |
|---|---|
| Cancer: | Sarcoma |
| Drug: | Xalkori (crizotinib) (ALK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Loss of 5'ALK leads to better response to crizotinib in sarcomas with ALK rearrangement
Published date:
05/19/2021
Excerpt:
Case #2 is an undifferentiated sarcoma with 2 ALK fusions, RANBP2-ALK and TMEM217-ALK…All cases received and responded to Crizotinib therapy, with the Karnofsky Performance Status (KPS) improved from 30-60 score pre-therapy to 90-100 score after 3 months of Crizotinib.…case#1 and #2, both lost 5'ALK, remain progression-free at 15m and 27m, respectively.
DOI:
10.1200/JCO.2021.39.15_suppl.e23554
