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    Association details:
    Biomarker:RAD51C expression
    Cancer:Germ Cell Tumors
    Drug:Lynparza (olaparib) (PARP inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    Mol Oncol
    Title:

    Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors

    Published date:
    01/01/2021
    Excerpt:
    ...we demonstrated the sensitivity of TGCT cell lines to Olaparib, which associated with differential methylation levels of a subset of targets, namely BRCA1 and RAD51C...the cell line least responsive to Olaparib (TCam-2) presented the highest BRCA1 and RAD51C expression levels.
    DOI:
    10.1002/1878-0261.12909