As depicted in Figure 8(F), PTTG1 expression was significantly associated with overall survival in multivariate regression in the FUSCC cohort….The retrospective analysis (Figure 8(G,H)) indicated that elevated PTTG1 expression was significantly associated with better ICB response (χ2=3.99, p < .05) and PTTG1 may serve as a stable biomarker for immunotherapy (AUC = 0.679, p = .009)....As a higher PTTG1 expression level was significantly associated with ICB response, high PTTG1 expression may be also associated with a better prognosis among pRCC patients receiving ICB.