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Association details:
Biomarker:PTPN1 overexpression
Cancer:Colorectal Cancer
Drug:claramine (PTP-1B inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
New
Title:

Protein Tyrosine Phosphatase-1B Inhibition Disrupts IL13Ra2-Promoted Invasion and Metastasis in Cancer Cells

Excerpt:
The interactome of IL13Rα2 was determined in GBM by using a proteomic analysis and then validated in CRC and OC...Animal models of GBM and metastatic CRC were used for testing PTP1B inhibitors…An in silico analysis revealed that PTP1B overexpression is associated with lower overall survival of patients in the three types of cancer.
DOI:
10.3390/cancers12020500