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Association details:
| Biomarker: | PTP4A3 overexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Erbitux (cetuximab) (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells
Excerpt:
...elevated PRL-3 (PTP4A3) expression ranked first, sixth, and fourth (of 110 genes) in terms of correlation with a favorable objective response, disease control, and progression-free survival, respectively, in an independent cetuximab-treated CRC patient cohort. Collectively, these clinical results support our in vitro observations that a high level of PRL-3 expression induces sensitivity to EGFR inhibition due to addiction to activated EGFR.
DOI:
10.1172/jci66824