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Association details:
| Biomarker: | PTEN P204S |
|---|---|
| Cancer: | Melanoma |
| Drug Class: | BRAF inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
PTEN Loss-of-Function Alterations Are Associated With Intrinsic Resistance to BRAF Inhibitors in Metastatic Melanoma
Excerpt:
We analyzed 66 tumors from patients with metastatic BRAF-mutant melanoma...Alterations in PTEN were significantly more common in patients with poor response grade treated with BRAFi monotherapy...Of the 11 PTEN alterations identified in the poor response grade cohort, 10 were likely inactivating, including deep deletions consistent with homozygous loss (n = 5), truncating mutations (n = 4), and one missense mutation (P204S)...
DOI:
10.1200/PO.16.00054
