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Association details:
| Biomarker: | PTEN N323fs*21 |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | everolimus (mTOR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Exceptional Response to Everolimus in a Patient with Metastatic Castrate-Resistant Prostate Cancer Harboring a PTEN Inactivating Mutation
Published date:
04/27/2020
Excerpt:
A 67-year-old male was noted to have an elevated prostate-specific antigen (PSA)...Further testing included a prostate biopsy that demonstrated Gleason grade 5 + 4 = 9 prostate adenocarcinoma in both lobes of the prostate…After being heavily pretreated, the patient showed stable disease on everolimus...
DOI:
10.1159/000506625
