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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway

Excerpt:
Antitumor efficacy of GDC-0980 was investigated in vivo in 3 xenograft models in combination with DTX: (i) MX-1 is a breast cancer model that lacks PTEN protein expression,...However, the combination of GDC-0980 and DTX resulted in tumor regressions in all 3 xenograft model evaluated.
DOI:
10.1158/1535-7163.MCT-11-0446