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Association details:
| Biomarker: | PTEN expression |
|---|---|
| Cancer: | Bladder Cancer |
| Drug: | everolimus (mTOR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
PTEN deficiency is associated with reduced sensitivity to mTOR inhibitor in human bladder cancer through the unhampered feedback loop driving PI3K/Akt activation
Excerpt:
In the current study, using archival tumours (not displaying PI3KCA mutations), we found that patients with no or low tumour expression of PTEN (Supplementary Figure 1) had a shorter PFS than patients with PTEN expression (median survival 61 vs 119 days, respectively, exploratory log-rank P=0.002) (Figure 1).
DOI:
10.1038/bjc.2013.505
