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Association details:
| Biomarker: | PRR13 overexpression |
|---|---|
| Cancer: | Ovarian Cancer |
| Regimen: | CaT |
| Direction: | Resistant |
Evidence:
Source:
Title:
Predictive value of ATP7b, BRCA1, BRCA2, PARP1, UIMC1 (RAP80), HOXA9, DAXX, TXN (TRX1), THBS1 (TSP1) and PRR13 (TXR1) genes in patients with epithelial ovarian cancer who received platinum-taxane first-line therapy
Excerpt:
Microdissected formalin-fixed tumoral samples from 187 EOC patients’ primary tumors (90 and 97 samples from matched patients in the experimental and validation sets, respectively) were analyzed....Most of the patients (172 out of 187) received front-line carboplatin-paclitaxel regimen....High TXR1 expression was associated with decreased PFS (P<0.001) and OS (P<0.001).
DOI:
10.1038/tpj.2016.63