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Association details:
| Biomarker: | PPP1R15B overexpression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | salubrinal (eIF2α dephosphorylation inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Super-Enhancer-Driven PPP1R15B As an Oncogenic and Potential Therapeutic Target in Multiple Myeloma
Published date:
12/24/2021
Excerpt:
Salubrinal inhibited MM cell proliferation in a dose-dependent manner, and MM cell lines with higher R15B expression were more sensitive to Salubrinal than those with lower R15B level...Salubrinal selectively inhibits proliferation of MM cells with high R15B expression. Hence, we propose that targeting R15B may serve as a new approach for effective anti-myeloma therapy.
DOI:
10.1182/blood-2021-149006
Source:
Title:
Super-Enhancer-Driven PPP1R15B is Oncogenic in Multiple Myeloma and Could Be Therapeutically Targeted
Published date:
04/14/2021
Excerpt:
...we examine the therapeutic effects of salubrinal on MM cells. Salubrinal inhibited MM cell proliferation in a dosedependent manner and MM cell line with higher R15B expression was more sensitive to salubribal than cell line with low R15B.
